What is Mediator® PA?
Mediator PA is a natural muscle building supplement that has been shown to directly activate mTOR -- the signaling pathway that drives muscle protein synthesis in humans. Research involving resistance-trained athletes has found that supplementing with Mediator PA leads to increases in lean mass gains, muscle strength, and body fat loss.[1,2]
Mediator PA is an ultra-premium form of phosphatidic acid (PA) from ingredient innovators, ChemiNutra. Phosphatidic Acid (PA) is a lipid messenger that accelerates muscle protein synthesis by stimulating the Mechanistic Target of Rapamycin (mTOR) pathway.
Benefits of Mediator PA
Increased Size & Strength
Research has shown that lifters taking phosphatidic acid (750mg/day = 1500mg Mediator PA):
Increased their squat strength by 12.7%
Increased lean body mass by 2.6%[1,2]
Fat Loss & Body Recomposition
Individuals supplementing with phosphatidic acid, in conjunction with resistance training, lost 2.8 pounds of body fat compared to only 1.1 pounds of fat loss for the control group.[2]
Aids Recovery
Muscle growth and recovery is ultimately a balance of protein synthesis vs protein breakdown.
In addition to stimulating protein synthesis, Phosphatidic Acid (PA) may help limit catabolism by reducing the expression of a set of genes that encourage muscle protein breakdown.[3]
High Bioavailability
Phosphatidic acid offers high bioavailability and has been shown to be efficiently absorbed and utilized in humans when taken orally (the same of which CANNOT be said for other “natural muscle building supplements”).[4]
High Safety Profile
Phosphatidic acid is natural and non-hormonal.
References
Hoffman JR, Stout JR, Williams DR, et al. Efficacy of phosphatidic acid ingestion on lean body mass, muscle thickness and strength gains in resistance-trained men. Journal of the International Society of Sports Nutrition. 2012;9:47. doi:10.1186/1550-2783-9-47.
Joy JM, Lowery RP, Dudeck JE, De-Souza EO, Jager R, McCleary SA, Wilson SMC, Purpura M, Wilson JM. Phosphatidic Acid Supplementation Increases Skeletal Muscle Hypertrophy and Strength. Poster presentation at the ISSN Conference 2013
Bond, P. (2017). Phosphatidic acid : biosynthesis , pharmacokinetics , mechanisms of action and effect on strength and body composition in resistance-trained individuals, 1–9. https://doi.org/10.1186/s12986-017-0166-6
Purpura M, Jager R, Joy JM, Lowery RP, Moore JD, Wilson JM. Effect of Oral Administration of Soy-Derived Phosphatidic ACid on Concentrations of Phosphatidic Acid and lyso-Phosphatidic Acid Molecular Species in Human Plasma. Poster Presentation at the ISSN Conference 2013.